Abstract: In this case study of an unique instance, effects of medium-energy, high-focused extracorporeal generated shock waves (ESW) onto the skin and the underlying fat tissue of a cellulite afflicted, 50-year-old woman were investigated. The treatment consisted of four ESW applications within 21 days. Diagnostic high-resolution ultrasound (Collagenoson) was performed before and after treatment. Directly after the last ESW application, skin samples were taken for histopathological analysis from the treated and from the contra-lateral untreated area of skin with cellulite. No damage to the treated skin tissue, in particular no mechanical destruction to the subcutaneous fat, could be demonstrated by histopathological analysis. However an astounding induction of neocollageno- and neoelastino-genesis within the scaffolding fabric of the dermis and subcutis was observed. The dermis increased in thickness as well as the scaffolding within the subcutaneous fat-tissue. Optimization of critical application parameters may turn ESW into a noninvasive cellulite therapy.
Conclusion: The application of external and internal forces are considered to be able to regulate gene expression and cell behavior. In particular, cell stretch is considered to be a stimulus supporting cell proliferation (skin expanders). The signaling pathways linking mechanical stretch to cell proliferation and survival (eg, activation of anti-apoptotic kinase PKB/Act) are still not well described.
These encouraging results put forward that optimization of critical application parameters may turn ESW into a noninvasive cellulite therapy, not by reduction of subcutaneous fat, but by strengthening the skin’s scaffolding fabric, particularly of the dermis and the subcutaneous fat tissue.
Further studies should show whether parameters such as the patient’s age (adolescent, adult or elderly females), body-composition (obesity), and the stage of cellulite have an influence on the outcome of ESW treatment. In our case, a histological analysis was possible by a planned operation symmetrical and at the same sites. In implementing a study with many participants, a noninvasive method of analysis must be applied such as high-resolution ultrasound.
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